The Nutrition Division investigates the impact of foods, nutrients, and eating patterns in clinical- and population-based settings. Specific areas of study include:
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Clinical Trial – MOMFIT
Maternal-Offspring Metabolics Family Intervention Trial (MOMFIT); funded by NHLBI/NIDDK as part of the LIFE Moms Consortium of seven centers collaborating on the prevention of excessive gestational weight gain in overweight/obese pregnant mothers. Moms and babies (n=300) will be followed for 12 months postpartum.
Epidemiologic Nutrition Research
Continuing analyses regarding existing cohorts, CARDIA, WHI, MESA: HCHS:SOL; SOL-Youth include diet quality and calibration studies combining diet assessment methodology with biomarker measures. Details follow:
- Women’s Health Initiative (WHI) Follow-up Study: ongoing research involving all of the post-menopausal women enrolled in the WHI
- Diet Intervention Study in Children (DISC) follow-up studies on this multi-center collaborative trial on adolescents who had elevated LDL-cholesterol levels and were randomized to a fat-modified diet and followed for ten years
- Coronary Risk Reduction in Young Adults (CARDIA) follow-up analyses in this cohort now in its 30th year of follow up
- International Study of Macro-micro-nutrients and Blood Pressure (INTERMAP) ongoing nutrient analyses within this cohort of middle-aged adults from China, Japan, the United Kingdom and the United States; inclusion of biomarkers and metabolomics measures is ongoing
- Hispanic Community Health Study: Study of Latinos (HCHS: SOL) Multi-center, observational study among Hispanic populations in San Diego, Chicago, the Bronx and Miami ; studying diet and lifestyle and cardiovascular risk factors in this population
- SOL-Youth is an ancillary study to the above HCHS: SOL study, funded by NHLBI. We are screening the offspring, children ages 8-15, of the HCHS-SOL participants; lifestyle, including diet and physical activity as well as clinical measures, to help determine the risk factor development in this population and how parental influence, acculturation and other sociodemographic factors may influence cardiovascular risk in the children and their parents
Our division wants to pursue many topic in our future research, including:
- Combining Mediterranean Diet quality scoring with DASH, USDG (HEI/AHEI) to better determine a universal diet quality score that is outcomes oriented
- Statistical modeling for optimizing the diet
- Maternal fetal epigenetic measures; diet and biomarkers
- Nutrients as inflammatory modulators: further investigation and specificity on best objective measures
- Roots of chronic disease beginning in utero/childhood: proposal of MOMFIT ancillary studies
- Global and Public Health Nutrition: Shifts from complex to refined carbohydrates and the unintended consequences
- Fat/Salt/Sugar: measurement and intervention related to prevention of chronic disease
- Comparative effectiveness research using the EDW and initiating standardized diet/nutritional assessment among NMH/NMPG patients
- BIG DATA- Nutrient/phytochemical intake vs. DRI vs. outcome measures of chronic disease
- Continue and enhance role of nutrition in Sleep and Cognitive Function research
- Primary Goal: Recruitment of additional and diverse nutrition faculty to facilitate research efforts in cancer/diabetes/obesity/and yet to be addressed outcomes.