Northwestern University Feinberg School of Medicine

Department of Preventive Medicine

Clinical Trials

As part of an academic medical center, the Department of Preventive Medicine (Feinberg) aims to improve the human health through scientific research. 

About Clinical Trials

Clinical trials test or study drugs, surgical procedures, medical devices, or interventions with human subjects. They look to determine their safety and effectiveness in relation to treating specific diseases. Clinical trials are part of clinical research and are at the heart of all medical advances. 

Preventive Medicine Clinical Trials

The following searchable list includes all Department of Preventive Medicine clinical trials currently looking for participants.

Trials
Stepped Telemental Health Care Intervention for Depression
TeleHealth Study: Researchers are studying the use of technology to make options for managing depression more affordable and easier for people to access. This study aims to evaluate different methods for addressing symptoms of depression. The…
TeleHealth Study: Researchers are studying the use of technology to make options for managing depression more affordable and easier for people to access. This study aims to evaluate different methods for addressing symptoms of depression. These methods include two different investigative study treatments. Eligible participants will be randomly assigned to receive one of two study interventions: 1) Telephone Administered Cognitive Behavioral Therapy Weekly, 50 minute study therapy sessions over the phone with a trained study clinician; OR… 2) Internet Administered Cognitive Behavioral Therapy Access to a study treatment website plus email and phone support from a trained study clinician. Participants in the iCBT intervention may eventually receive weekly 50 minute telephone study therapy sessions. Study treatment lasts for a maximum of 20 weeks in all interventions. If depression symptoms improve, study treatment may be ended earlier than 20 weeks. Participants will be compensated up to $200 for completing telephone interviews and questionnaires online across an 11-month period.
Individuals who are currently experiencing clinical symptoms of depression, who are at least 18 years old, who speak English, and have access to and familiarity of using the Internet and phones might be a good fit for this study.
Mohr, David CMohr, David C
NCT01906476 STU00064411
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Study Coordinator 855 682 2487
Extended Varenicline Treatment for Smoking Among Cancer Patients
The purpose of this study is to compare two different smoking cessation treatments for people who have been diagnosed or been treated for cancer in the past 5 years. Participants will receive either standard varenicline (Chantix) treatm…
The purpose of this study is to compare two different smoking cessation treatments for people who have been diagnosed or been treated for cancer in the past 5 years. Participants will receive either standard varenicline (Chantix) treatment for 12 weeks or extended varenicline (Chantix) treatment for 24 weeks, in combination with brief behavior therapy.
1. 18 years of age or older who self-report smoking at least 5 cigarettes (menthol and non-menthol) per day, on average, for the last 6 months.
2. Current cancer diagnosis (all sites) or diagnosis within the past 5 years.
3. Able to use varenicline safely, based on a medical evaluation including medical history and physical examination, and psychiatric evaluation.
Hitsman, Brian LHitsman, Brian L
NCT01756885 STU00064871
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Maloney, Michael 1 877 236 7487
Artificial Intelligence in a Mobile Intervention for Depression and Anxiety (AIM)
IntelliCare Study: Researchers are studying the use of smartphone apps to teach mood management skills to people experiencing depression and anxiety. The apps work to target common issues related to depression and anxie…
IntelliCare Study: Researchers are studying the use of smartphone apps to teach mood management skills to people experiencing depression and anxiety. The apps work to target common issues related to depression and anxiety, like feeling down, stressed, or worried. Eligible participants would be asked to download the IntelliCare apps onto their own Android smartphone, and use the apps each day for an 8-week period. Participants will be randomly assigned to either use the apps independently or communicate via phone and through text messages with an IntelliCare coach who will help with the use of the apps. Individuals will participate in the 8 week IntelliCare program, during which, two online assessments will be completed. Follow-up online assessments will be conducted 3 and 6 months after the 8 week program. In sum, the IntelliCare study lasts up to 8 months. Participants may be compensated up to $160 in total for completing the study assessments.
You may be eligible to join if you are an (1) Android smartphone user with a data/text messaging plan, (2) currently experiencing symptoms of depression or anxiety, (3) a United States Citizen/Resident, (4) at least 18 years old, and (5) a new user of IntelliCare apps.
Mohr, David CMohr, David C
STU00074405
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For more information on this study please contact us:

Study Coordinator 855 682 2487
CENTER FOR BEHAVIORAL INTERVENTION TECHNOLOGIES (CBITs) RESEARCH SUBJECT RECRUITMENT REGISTRY
WHAT IS THE REGISTRY ABOUT? Becoming a member of this registry allows researchers at Northwestern University to get in touch with you to see if you might be interested in and eligible to participate in diff…
WHAT IS THE REGISTRY ABOUT? Becoming a member of this registry allows researchers at Northwestern University to get in touch with you to see if you might be interested in and eligible to participate in different research studies at CBITs. The research conducted at CBITs generally involves evaluating different aspects of technology-assisted health interventions. WHAT WILL I BE ASKED TO DO? You will be asked to provide some basic contact and background information, as well as continue on to complete a brief survey. There is no cost to join the registry. You can read more about the current studies and sign up for the registry on our website: http://cbitshealth.northwestern.edu
If you're an adult (18 years or older), living in the United States, who speaks English, and has Internet access, you may be eligible to join.
Mohr, David CMohr, David C
STU00076804
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For more information on this study please contact us:

Study Coordinator 855 682 2487
Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
We are recruiting people motivated to lose weight to participate in a 6 month weight loss intervention study. The purpose of this study is to see what combination of different weight loss program components is t…
We are recruiting people motivated to lose weight to participate in a 6 month weight loss intervention study. The purpose of this study is to see what combination of different weight loss program components is the most effective for overall weight loss. All participants will receive a personal coach who will communicate with them regularly over the telephone throughout the study. All participants must own a personal smartphone and be willing and able to record their food intake on a smartphone application that will be provided. Participants will be randomly assigned to 1 of 16 possible programs that may include a combination of the following weight loss program components: Coaching Calls, Text Messaging, Reports to Primary Care Physician, Buddy Training, Meal Replacement Recommendations. Participants are asked to attend a total of 5 in-person sessions throughout the course of the study, and all appointments will be held on Northwestern University's Chicago campus at 680 N. Lake Shore Drive. Chicago, IL 60611. Free parking vouchers will be provided for those who drive to in-person visits. This study DOES NOT involve medication/drugs.
You may be eligible to participate if you: Are between 18-60 years old; Will be living in the Chicagoland area for the next 6 months; Are NOT currently pregnant, trying to become pregnant, or breastfeeding; Do NOT have an unstable medical condition; Have an Android or iPhone smartphone; Are willing to track your lifestyle behaviors using a smartphone for 6-months
Spring, BonnieSpring, Bonnie
NCT01814072 STU00066546
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Paluch, Amanda 773 234 6711
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
The goal of this study is to develop a new combined treatment to help individuals with clinical depression to quit smoking. Participants will receive one of four treatments: 1) Standard behavior therapy + placebo; 2) Beh…
The goal of this study is to develop a new combined treatment to help individuals with clinical depression to quit smoking. Participants will receive one of four treatments: 1) Standard behavior therapy + placebo; 2) Behavioral activation for smoking cessation + placebo; 3) Standard behavior therapy + varenicline (Chantix); or 4) Behavioral activation for smoking cessation + varenicline (Chantix).
1. Adult (18 years of age or older) daily cigarette smokers (1+ cigarettes per day)
2. Lifetime history of clinical depression (Major Depressive Disorder)
Hitsman, Brian LHitsman, Brian L
NCT02378714 STU00100303
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Reyes, Celine 1 877 236 7487
SMART Weight Loss Management
SMART is a 12-month weight loss research study taking place in the Department of Preventive Medicine at Northwestern University. SMART includes a 3-month weight loss program at no cost. The purpose of this research is to determine the best initial strategy for weight loss…
SMART is a 12-month weight loss research study taking place in the Department of Preventive Medicine at Northwestern University. SMART includes a 3-month weight loss program at no cost. The purpose of this research is to determine the best initial strategy for weight loss and best follow-up approach for those who need more support from a weight loss program
You are between the ages of 18 - 60 years old.
You will live in the Chicagoland area for the next 12 months.
You are NOT currently pregnant, trying to become pregnant, or breastfeeding.
You do NOT have an unstable medical condition.
You own an Android or iPhone smartphone.
You are willing to track your lifestyle behaviors using a smartphone for 3 months.
Spring, BonnieSpring, Bonnie
  • Map it 680 N. Lake Shore Drive Suite 1410
    Chicago, IL
NCT02997943 STU00202075
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Martindale, Laura 312 503 1395
AHA Strategically Focused Research Network: mHealth Intervention to Preserve and Promote Ideal Cardiovascular Health-Study 2
NUYou is a two year cardiovascular health study using a mobile app.
The study is closed to recruiting. To test whether a health intervention in the form of a mobile phone
application will preserve or improve heart healthy behaviors (nonsmoking, healthy diet, physical
activity, healthy weight) and cardiovascular health biomarkers (blood pressure, and fasting
cholesterol and glucose) in college students between their freshman and junior year.
Spring, BonnieSpring, Bonnie
STU00202845
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Hood, Susan 312 503 0945
NIH All of Us Research Program Precision Medicine Initiative® Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers
Northwestern Medicine is a partner of the All of Us Research Program in Illinois. All of Us is an exciting new initiative from the National I…
Northwestern Medicine is a partner of the All of Us Research Program in Illinois. All of Us is an exciting new initiative from the National Institutes of Health (NIH). The mission is simple: to speed up health research and medical breakthroughs. To do this, the All of Us Research Program is asking one million people to lead the way to provide the types of information that can help us create individualized prevention, treatment, and care for all of us. Visit nm.org/joinallofus to learn more and enroll.
- 18 years of age or older
- Currently live in the United States
- Currently receive or have ever received care at a Northwestern Medicine (NM) facility or with an NM health provider (such as doctor, physical therapist, NM Immediate Care, etc.) including Northwestern Medical Group, Regional Medical Group, KishHealth Physician Group, Northwestern Memorial Hospital, Lake Forest Hospital, Grayslake Outpatient Center, Central DuPage Hospital, Delnor Hospital, Kishwaukee Hospital, Valley West Hospital or Marianjoy Rehabilitation Hospital.
Greenland, PhilipGreenland, Philip
  • Map it 201 E. Huron St.
    Chicago, IL
STU00204480
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Dahdouh, Rabih 1 312 695 6077