Northwestern University Feinberg School of Medicine

Department of Preventive Medicine

Clinical Trials

As part of an academic medical center, the Department of Preventive Medicine (Feinberg) aims to improve the human health through scientific research. 

About Clinical Trials

Clinical trials test or study drugs, surgical procedures, medical devices, or interventions with human subjects. They look to determine their safety and effectiveness in relation to treating specific diseases. Clinical trials are part of clinical research and are at the heart of all medical advances. 

Preventive Medicine Clinical Trials

The following searchable list includes all Department of Preventive Medicine clinical trials currently looking for participants.

Trials
Stepped Telemental Health Care Intervention for Depression
TeleHealth Study: Researchers are studying the use of technology to make options for managing depression more affordable and easier for people to access. This study aims to evaluate different methods for addressing symptoms of depression. The…
TeleHealth Study: Researchers are studying the use of technology to make options for managing depression more affordable and easier for people to access. This study aims to evaluate different methods for addressing symptoms of depression. These methods include two different investigative study treatments. Eligible participants will be randomly assigned to receive one of two study interventions: 1) Telephone Administered Cognitive Behavioral Therapy Weekly, 50 minute study therapy sessions over the phone with a trained study clinician; OR… 2) Internet Administered Cognitive Behavioral Therapy Access to a study treatment website plus email and phone support from a trained study clinician. Participants in the iCBT intervention may eventually receive weekly 50 minute telephone study therapy sessions. Study treatment lasts for a maximum of 20 weeks in all interventions. If depression symptoms improve, study treatment may be ended earlier than 20 weeks. Participants will be compensated up to $200 for completing telephone interviews and questionnaires online across an 11-month period.
Individuals who are currently experiencing clinical symptoms of depression, who are at least 18 years old, who speak English, and have access to and familiarity of using the Internet and phones might be a good fit for this study.
Mohr, David CMohr, David C
NCT01906476 STU00064411
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For more information on this study please contact us:

Study Coordinator 855 682 2487
Artificial Intelligence in a Mobile Intervention for Depression and Anxiety (AIM)
IntelliCare Study: Researchers are studying the use of smartphone apps to teach mood management skills to people experiencing depression and anxiety. The apps work to target common issues related to depression and anxie…
IntelliCare Study: Researchers are studying the use of smartphone apps to teach mood management skills to people experiencing depression and anxiety. The apps work to target common issues related to depression and anxiety, like feeling down, stressed, or worried. Eligible participants would be asked to download the IntelliCare apps onto their own Android smartphone, and use the apps each day for an 8-week period. Participants will be randomly assigned to either use the apps independently or communicate via phone and through text messages with an IntelliCare coach who will help with the use of the apps. Individuals will participate in the 8 week IntelliCare program, during which, two online assessments will be completed. Follow-up online assessments will be conducted 3 and 6 months after the 8 week program. In sum, the IntelliCare study lasts up to 8 months. Participants may be compensated up to $160 in total for completing the study assessments.
You may be eligible to join if you are an (1) Android smartphone user with a data/text messaging plan, (2) currently experiencing symptoms of depression or anxiety, (3) a United States Citizen/Resident, (4) at least 18 years old, and (5) a new user of IntelliCare apps.
Mohr, David CMohr, David C
STU00074405
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For more information on this study please contact us:

Study Coordinator 855 682 2487
CENTER FOR BEHAVIORAL INTERVENTION TECHNOLOGIES (CBITs) RESEARCH SUBJECT RECRUITMENT REGISTRY
WHAT IS THE REGISTRY ABOUT? Becoming a member of this registry allows researchers at Northwestern University to get in touch with you to see if you might be interested in and eligible to participate in diff…
WHAT IS THE REGISTRY ABOUT? Becoming a member of this registry allows researchers at Northwestern University to get in touch with you to see if you might be interested in and eligible to participate in different research studies at CBITs. The research conducted at CBITs generally involves evaluating different aspects of technology-assisted health interventions. WHAT WILL I BE ASKED TO DO? You will be asked to provide some basic contact and background information, as well as continue on to complete a brief survey. There is no cost to join the registry. You can read more about the current studies and sign up for the registry on our website: http://cbitshealth.northwestern.edu
If you're an adult (18 years or older), living in the United States, who speaks English, and has Internet access, you may be eligible to join.
Mohr, David CMohr, David C
STU00076804
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For more information on this study please contact us:

Study Coordinator 855 682 2487
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
The goal of this study is to develop a new combined treatment to help individuals with clinical depression to quit smoking. Participants will receive one of four treatments: 1) Standard behavior therapy + placebo; 2) Beh…
The goal of this study is to develop a new combined treatment to help individuals with clinical depression to quit smoking. Participants will receive one of four treatments: 1) Standard behavior therapy + placebo; 2) Behavioral activation for smoking cessation + placebo; 3) Standard behavior therapy + varenicline (Chantix); or 4) Behavioral activation for smoking cessation + varenicline (Chantix).
1. Adult (18 years of age or older) daily cigarette smokers (1+ cigarettes per day)
2. Lifetime history of clinical depression (Major Depressive Disorder)
Hitsman, Brian LHitsman, Brian L
NCT02378714 STU00100303
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Reyes, Celine 1 877 236 7487
SMART Weight Loss Management
SMART is a 12-month weight loss research study taking place in the Department of Preventive Medicine at Northwestern University. SMART includes a 3-month weight loss program at no cost. The purpose of this research is to determine the best initial strategy for weight loss…
SMART is a 12-month weight loss research study taking place in the Department of Preventive Medicine at Northwestern University. SMART includes a 3-month weight loss program at no cost. The purpose of this research is to determine the best initial strategy for weight loss and best follow-up approach for those who need more support from a weight loss program
You are between the ages of 18 - 60 years old.
You will live in the Chicagoland area for the next 12 months.
You are NOT currently pregnant, trying to become pregnant, or breastfeeding.
You do NOT have an unstable medical condition.
You own an Android or iPhone smartphone.
You are willing to track your lifestyle behaviors using a smartphone for 3 months.
Spring, BonnieSpring, Bonnie
  • Map it 680 N. Lake Shore Drive Suite 1410
    Chicago, IL
NCT02997943 STU00202075
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Scanlan, Laura 312 503 1395
AHA Strategically Focused Research Network: mHealth Intervention to Preserve and Promote Ideal Cardiovascular Health-Study 2
NUYou is a two year cardiovascular health study using a mobile app.
The study is closed to recruiting. To test whether a health intervention in the form of a mobile phone
application will preserve or improve heart healthy behaviors (nonsmoking, healthy diet, physical
activity, healthy weight) and cardiovascular health biomarkers (blood pressure, and fasting
cholesterol and glucose) in college students between their freshman and junior year.
Spring, BonnieSpring, Bonnie
STU00202845
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Hood, Susan 312 503 0945
NCI 2015-06-03 Statin Therapy to Reduce Disease Progression from Liver Cirrhosis to Cancer
The purpose of this study is to compare the safety and effects of simvastatin in people with liver cirrhosis who are at an increased risk for liver cancer. In this study, you will get either simvastatin 40 mg d…
The purpose of this study is to compare the safety and effects of simvastatin in people with liver cirrhosis who are at an increased risk for liver cancer. In this study, you will get either simvastatin 40 mg daily or placebo daily, a pill that looks like simvastatin 40 mg but contains no medication. Simvastatin is approved by the U.S. Food and Drug Administration (FDA) to reduce the risk for heart attack, stroke, and chest pain in patients who have heart disease or risk factors for heart disease such as smoking, high blood pressure, low high-density lipoprotein (HDL), or family history of early heart disease. It is also approved to lower the risk for heart attack or stroke in patients with type 2 diabetes and risk factors such as diabetic eye or kidney problems, smoking, or high blood pressure. However, simvastatin is not approved by the FDA to decrease the risk of liver cancer. Simvastatin is considered “investigational” (a study drug) in this study. Studies show that simvastatin lowers the risk of heart disease not only by decreasing cholesterol, but also by decreasing inflammation. We believe that this anti-inflammatory effect of simvastatin may help patients with liver cirrhosis.
Confirmed diagnosis of liver cirrhosis assessed by the presence of clinical signs, symptoms, body imaging (ultrasound, computed tomography [CT], or magnetic resonance imaging [MRI]), or liver biopsy
Eastern Cooperative Oncology Group (ECOG) performance status =< 1 (Karnofsky >= 70%)
Leukocytes >= 2,500/microliter
Absolute neutrophil count >= 1,500/microliter
Platelets >= 50,000/microliter
Hemoglobin >= 10 g/dL
Total bilirubin =< 3 x institutional upper limit of normal (ULN)
Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 5 x institutional ULN
Creatinine =< 1.5 x institutional ULN
Women who are able to become pregnant must have a confirmed negative pregnancy test result prior to enrollment; women >= 50 years of age who have not had a menstrual period in the past year; and women who have had a hysterectomy, both ovaries removed, or a tubal ligation; will not be required to have a pregnancy test
Women who are able to become pregnant must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her study physician immediately
Ability to understand and the willingness to sign a written informed consent document and medical release
Willing and able to comply with trial protocol and follow-up
Have had an abdominal imaging test (CT, MRI, or ultrasound) within the past 7 months
Kulik, Laura MKulik, Laura M
  • Map it 675 N. St. Clair St.
    Chicago, IL
NCT02968810 STU00204992
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Sipich, Kimberly A 312 694 1293
NIH All of Us Research Program Precision Medicine Initiative® Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers
Northwestern Medicine is a partner of the All of Us Research Program in Illinois. All of Us is an exciting new initiative from the National I…
Northwestern Medicine is a partner of the All of Us Research Program in Illinois. All of Us is an exciting new initiative from the National Institutes of Health (NIH). The mission is simple: to speed up health research and medical breakthroughs. To do this, the All of Us Research Program is asking one million people to lead the way to provide the types of information that can help us create individualized prevention, treatment, and care for all of us. Visit nm.org/joinallofus to learn more and enroll.
- 18 years of age or older
- Currently live in the United States
- Currently receive or have ever received care at a Northwestern Medicine (NM) facility or with an NM health provider (such as doctor, physical therapist, NM Immediate Care, etc.) including Northwestern Medical Group, Regional Medical Group, KishHealth Physician Group, Northwestern Memorial Hospital, Lake Forest Hospital, Grayslake Outpatient Center, Central DuPage Hospital, Delnor Hospital, Kishwaukee Hospital, Valley West Hospital or Marianjoy Rehabilitation Hospital.
Greenland, PhilipGreenland, Philip
  • Map it 201 E. Huron St.
    Chicago, IL
STU00204480
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For more information on this study please contact us:

Dahdouh, Rabih 1 312 695 6077