Chiang-Ching (Spencer) Huang, PhD

Assistant Professor

Dr. Chiang-Ching (Spencer) Huang received his MS degree in Statistics from University of Iowa in 1998, and PhD in Biostatistics from University of Michigan in 2003. Dr. Huang's research has focused on gene expression analysis with application to cancer research. He is particularly interested in utilizing and developing novel data mining techniques to identify inherent patterns and associations between expression profiling and patients’ phenotype. He has helped develop an efficient method using proteomic/genomic data to identifying low stage high-risk patients in lung adenocarcinoma. He is also interested in the integrated analysis of various biological data, especially in the construction of genetic pathways. The development of efficient algorithms to combine gene expression data with location information, promoter sequences, gene ontology and others should open the door to better understanding of the complex mechanism in carcinogenesis.

Peer-Reviewed Publications

1. Guoan Chen, Hong Wang, Tarek G. Gharib, Chiang-Ching Huang, Dafydd G. Thomas, Kerby A. Shedden, Jeremy M. G. Taylor, Sharon L. R. Kardia, David E. Misek, Thomas J. Giordano, Mark D. Iannettoni, Mark B. Orringer, Samir M. Hanash, and David G. Beer: Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas. Molecular Cellular Proteomics, February 2003.

2. Guoan Chen, Tarek G. Gharib, Dafydd G. Thomas, Chiang-Ching Huang, David E. Misek, Rork D. Kuick, Thomas J. Giordano, Mark D. Iannettoni, Mark B. Orringer, Samir M. Hanash, and David G. Beer: Proteomic Analysis of EIF-5A in Lung Adenocarcinomas. Proteomics. 2003 Apr;3(4):496-504.

3. Donald R. Schwartz, Rong Wu, Sharon L.R. Kardia, Albert M. Levin, Chiang- Ching Huang, Kerby A. Shedden, Rork Kuick, David E. Misek, Samir M. Hanash, Jeremy M. G. Taylor, Heather Reed, Neali Hendrix, Yali Zhai, Eric R. Fearon, Kathleen R. Cho: Novel Candidate Targets of ß-catenin/TCF Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas. Cancer Research. 2003 Jun 1;63(11):2913-22.

4. Guoan Chen, Tarek G. Gharib, Hong Wang, Chiang-Ching Huang, Dafydd G. Thomas, Kerby A. Shedden, David E. Misek, Rork D. Kuick, Jeremy M.G. Taylor, Thomas J. Giordano, Sharon L.R. Kardia, Mark D. Iannettoni, Philip J. Hogg, Mark B. Orringer, Samir M. Hanash, and David G. Beer: Protein Expression Profiles Predict Patient Survival in Stage I Lung Adenocarcinoma. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13537-42.

5. Guoan Chen, Tarek G. Gharib, Chiang-Ching Huang, Jeremy M. G. Taylor, David E. Misek, Sharon L. R. Kardia, Thomas J. Giordano, Mark D. Iannettoni, Mark B. Orringer, Samir M. Hanash, and David G. Beer: Discordant Protein and mRNA Expression in Lung Adenocarcinomas. Molecular Cellular Proteomics, 1:314-322, April 2002.

6. David G. Beer, Sharon L.R. Kardia, Chiang-Ching Huang, Albert M. Levin, David E. Misek, Lin Lin, Guoan Chen, Tarek G. Gharib, Thomas J. Giordano, Dafydd G. Thomas, Michelle L. Lizyness, Rork Kuick, Satoru Hayasaka, Jeremy M.G. Taylor, Mark D. Iannettoni, Mark B. Orringer, Samir Hanash: Gene Expression Profiles Predict Survival in Lung Adenocarcinomas. Nature Medicine, 8, 816-824, 2002.

7. Tarek G. Gharib, Gouan Chen, Hong Wang, Chiang-Ching Huang, Michael S Prescott, Kerby A. Shedden, David E. Misek, Dafydd G. Thomas, Thomas J. Giordano, Jeremy Taylor, Sharon Kardia, John Yee, Mark B Orringer, Samir M. Hanash, David G. Beer: Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma. Neoplasia, Vol 4, No. 5, 440-448, September 2002.

8. Christopher J. Moran, Douoglas A. Arenberg, Chiang-Ching Huang, Thomas J. Giordano, Dafydd G. Thomas, David Misek, Samir Hanash, Mark D. Iannettoni, Mark B. Orringer, David G. Beer: RANTES expression by Lung Adenocarcinomas Cells is an Independent Predictor of Survival in Stage I Patients. Clinical Cancer Research, Vol. 8, 3803-3812, December 2002.

9. Guoan Chen, Tarek G. Gharib, Chiang-Ching Huang, Dafydd G. Thomas, Kerby A. Shedden, Jeremy M.G. Taylor, Sharon L.R. Kardia, David E. Misek, Thomas J. Giordano, Mark D. Iannettoni, Mark B. Orringer, Samir M. Hanash, and David G. Beer: Proteomic Analysis of Lung Adenocarcinoma: identification of a Highly Expressed Set of Proteins in Tumors. Clinical Cancer Research, Vol. 8, 2298-2305, July 2002.

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